You may occasionally see crystals due to the high concentration of peptides; evaporation, temperature, and/or atmospheric pressure. The solution is still effective. Last Update: October 20, 2018 October 20, 2018 2765FAQ’sRelated Knowledge Base Posts -Are your products tested on animals?How should you handle itchiness, erythema, and edema if experienced with PEPTI-a.c.n.e.?How is it that PEPTI-lift and PEPTI-tone have the same ingredients but different functions?